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This medicine can lower blood sodium levels while raising blood potassium levels. Excessively high potassium levels in blood sometimes cause potentially life-threatening abnormalities in heart rhythm. Therefore, Aldactone usually is not administered with other agents that can raise blood potassium levels. Aldactone can cause elevation of blood digoxin (Lanoxin) to toxic levels.
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Magnium and potassium-sparing diuretic and aldosterone antagonist. It competitively associates with aldosterone receptors in in the distal parts of the nephron. It has a diuretic effect, increases excretion of natrium ions and decreases excretion of potassium and magnium, decreases urinary acidity. The diuretic effect of the medicine is moderate and appears usually after 2-5 days of treatment and continues during 2-3 days after discontinuance of the medicine intake. A weak hypotension effect appear usually in 2-3 weeks of treatment. Aldactone is used in combination with other drugs to treat hypertension. It also facilitates removal of excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease.
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