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The first product used for this purpose DES diethylstilbestrol was approved for use in beef cattle in 1954.
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McMicheal AJ, Griffiths CE, Talwar HS, et al.
; Dougherty-Page, J.
The conversion of linoleic acid to gla can be disrupted by modern food preparation, vitamin and mineral deficiency as well as metabolic disorders such as diabetes, viral infection, hormonal changes and aging.
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The mean age of the subjects was 65 years, and the majority 94 was Caucasian.

J Clin Endocrinol.
A stimulus then returns the phospholipid to arachidonic acid, which is metabolized by certain enzymes mainly COX and LOX into prostaglandins, thromboxanes, and leukotrienes that are critical to yielding various disease manifestations, including constriction of blood vessels and bronchioles, changes in platelet function, and development of inflammation.
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Again, no central atom means we re talking about carbon, and any hydrogens are assumed to be there.
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Exposure of Syrian hamsters to stilbene estrogen DES produces several changes in the nuclei of target organ for carcinogenesis kidney 1 Products of nuclear redox reactions of DES modify transcription regulating proteins and DNA; 2 transcription is inhibited; 3 tyrosine phosphorylation of nuclear proteins, including RNA polymerase II, p53, and nuclear insulin-like growth factor-1 receptor, is altered; and 4 DNA repair gene DNA polymerase beta transcripts are decreased and mutated.
Use with caution in cirrhosis, ocular herpes simplex, hypertension, diverticulitis, hypothyroidism, myasthenia gravis, peptic ulcer disease, osteoporosis, ulcerative colitis, psychotic tendencies, renal insufficiency, pregnancy, diabetes mellitus, history of seizure disorders, multiple sclerosis, thromboembolic disorders, myocardial infarction.
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Clin Neurophysiol 2001;112 1946-51.
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