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Abilify is an add-on medication used for the treatment of major depressive disorder, schizophrenia, manic and mixed episodes associated with bipolar disorder in adults and children and adolescents and also of irritability associated with autistic disorder in pediatric patients. The mechanism of action of Abilify is unknown. It shows partial agonism at the D2 receptor, it is also a partial agonist at the 5-HT1A receptor, and also displays an antagonist profile at the 5-HT2A receptor. It has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.
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