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Furosemide is a loop diuretic causing fast and short diuresis. It possesses natriuretic effect and also decreases levels of Cl- in blood, increases excretion of K+, Ca2+, Mg2+. Penetrating into a renal tubule in ascending thick limb of Henle's loop it blocks re-absorption of Na+ and Cl-. Due to increased excretion of Na+ secondary intensified excretion of water occurs and as well as increased secretion of K+ in distal part of the renal tubule. Simultaneously excretion of Ca2+ and Mg2+ increases. Furosemide is used to treat edema syndrome in patients with chronic heart failure (degree II and III), cirrhosis, diseases of kidneys, acute heart failure (pulmonary edema), brain edema, hypertensive crisis, arterial hypertension and others.
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Hearing damage may occur if Furosemide is administered with aminoglycoside antibiotics (gentamicin and others) or Edecrin - another diuretic. Concomitant use of Furosemide and aspirin may cause high blood levels of aspirin and aspirin toxicity. Furosemide is able to reduce excretion of lithium by the kidneys. Sucralfate (Carafate) reduces the action of Furosemide. Intake of Ingestion of Furosemide and Sucralfate should be separated by two hours.
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