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Before using Furosemide, consult your doctor if you suffer from kidney disease, liver disease, gout, lupus, diabetes, or an allergy to sulfa drugs. Avoid becoming dehydrated as Furosemide makes you urinate more often. Do not stop taking the drug even if you feel fine as high blood pressure often has no symptoms. Avoid taking the drug if you are pregnant or breastfeeding.
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Furosemide is a loop diuretic causing fast and short diuresis. It possesses natriuretic effect and also decreases levels of Cl- in blood, increases excretion of K+, Ca2+, Mg2+. Penetrating into a renal tubule in ascending thick limb of Henle's loop it blocks re-absorption of Na+ and Cl-. Due to increased excretion of Na+ secondary intensified excretion of water occurs and as well as increased secretion of K+ in distal part of the renal tubule. Simultaneously excretion of Ca2+ and Mg2+ increases. Furosemide is used to treat edema syndrome in patients with chronic heart failure (degree II and III), cirrhosis, diseases of kidneys, acute heart failure (pulmonary edema), brain edema, hypertensive crisis, arterial hypertension and others.
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