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Take Abilify once a daily with or without food. The usual starting dose is 10 or 15 mg, later the dose may be increased to achieve the desired effect.
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Carbamazepine (Tegretol) decreases the levels of Abilifyole in the body stimulating the liver enzymes such as CYP3A4. Similar influence on Abilify is shown by phenytoin (Dilantin), rifampin (Rifadin, Rimactane, Rifadin, Rifater, Rifamate), and phenobarbital. Blocking of CYP3A4 by Ketoconazole (Nizoral) increases the amount of Abilify in the body. Other drugs with similar action are: itraconazole (Sporanox), fluconazole (Diflucan), voriconazole (Vfend), cimetidine (Tagamet), verapamil (Calan, Isoptin), diltiazem (Cardizem, Dilacor), erythromycin, clarithromycin (Biaxin), nefazodone (Serzone), ritonavir (Norvir), saquinavir (Invirase), nelfinavir (Viracept), indinavir (Crixivan), and grapefruit juice. Their action is not well studied though.
Quinidine (Quinaglute, Quinidex) inhibits another liver enzyme known as CYP2D6 and also is able to increase the levels of Abilify. Other medicines with similar action are fluoxetine (Prozac) and paroxetine (Paxil). Abilify may dangerously increase blood sugar levels in patients with diabetes.
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