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Inhibitors of cytochrome P450 (ketoconazole, quinidine, itraconazole, erythromycin, fluoxetine) increase, and its inducers (rifampin, phenytoin, carbamazepine, ethanol) reduce blood concentrations Aricept. The effect of Aricept can be unpredictably increased by cholinostimulators and weakened by choline inhibitors. Risk of adverse reactions increases when Aricept is used together with drugs for general anesthesia and NSAIDs.
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The most frequent adverse reactions include allergy symptoms (hives, rash, facial swelling), headache, dizziness, fatigue, coughing up blood or vomit that looks like blood or coffee grounds, painful or difficult urination, seizure (black-out or convulsions).
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