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Inhibitors of cytochrome P450 (ketoconazole, quinidine, itraconazole, erythromycin, fluoxetine) increase, and its inducers (rifampin, phenytoin, carbamazepine, ethanol) reduce blood concentrations Aricept. The effect of Aricept can be unpredictably increased by cholinostimulators and weakened by choline inhibitors. Risk of adverse reactions increases when Aricept is used together with drugs for general anesthesia and NSAIDs.
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Precautions
Aricept contains active ingredient donepezil hydrochloride which is an inhibitor of the enzyme acetylcholinesterase and hereby blocks disintegration of acetylcholine, which is responsible for the transfer of excitation in the central nervous system. Aricept slows progress of dementia caused by Alzheimer's disease.
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