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Nexium is a specific inhibitor of a proton pump (PPIs) of the parietal cells of the mucous layer of stomach. It is a form of Prilosec (Omeprazole). It is accumulated and transformed into an active form in the secretory tubules where it inhibits secretion of hydrochloric acid. Nexium is used to treat gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, promote healing of erosive esophagitis, eradication of Helicobacter pylori together with antibiotics, preventive therapy of ulcers after treatment with anti-inflammatory non-steroid medications.
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To treat GERD, 20 or 40 mg of Nexium is given once daily during 4-8 weeks. Treatment of conditions caused by H. pylori requires 40 mg of Nexium administered once daily in combination with amoxicillin and clarithromycin during 10 days. Take Nexium capsules one hour before a meal, do not chew or crush them, swallow them whole.
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