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Hypersensitivity, pregnancy, breastfeeding, estrogen depending malignant tumors, undiagnosed genital or uterine bleeding, thrombophlebitis or thromboembolic disease in active phase (excluding treatment of breast and prostate cancers). Cautiousness should be exercised in patients with thrombophlebitis, thrombosis or thromboembolism (while taking estrogens in history); family hyperlipoproteinemia, pancreatitis, endometriosis, gallbladder disease in history (especially cholelithiasis), severe liver failure, jaundice (including one during pregnancy in history), hepatic porphyria, leiomyoma, hypercalcemia associated with bone metastases caused by breast cancer, underactive thyroid, porphyria, endometriosis, asthma.
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Estrogens stimulate the liver's ability to produce factors that promote the clotting of blood. Thus, concomitant administration of Premarin and warfarin (blood thinner) may cause decrease their effects. Barbiturates, Rifampin (Rifadin), phenytoin (Dilantin), carbamazepine (Tegretol), griseofulvin (Grifulvin), St. John's wort and primidone increase metabolism of estrogens. Erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), and ritonavir (Norvir) act oppositely.
Take the missed dose as soon as you remember about it. If it is almost time of your next dose just skip it and return to your regular schedule.
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Premarin is a mixture of estrogen hormones which regulates development and functions of female reproductive system, formation of female secondary sex characteristics. On entering into the bloodstream it forms a complex with a specific receptor (in the fallopian tubes, cervix, excretory ducts of the mammary glands, vagina, urethra, breast, liver, hypothalamus, hypophisis), stimulates synthesis of DNA and proteins. It results in proliferation of the epithelium, increased sensitivity of the uterus and tubes muscles of to medications stimulatign their motility. This medication decreases bone resorption of Ca2 + in menopause, prevents involution of the genitals. Premarin is used to treat symptoms of menopause which include hot flashes, vaginal dryness, vaginal irritation and dryness, to prevent osteoporosis in postmenopausal women. Replacement therapy in peri- and postmenopausal women, ovarian hypofunction (primary and secondary amenorrhea, oligomenorrhea, dysmenorrhea) and other conditions.
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Hypersensitivity, pregnancy, breastfeeding, estrogen depending malignant tumors, undiagnosed genital or uterine bleeding, thrombophlebitis or thromboembolic disease in active phase (excluding treatment of breast and prostate cancers). Cautiousness should be exercised in patients with thrombophlebitis, thrombosis or thromboembolism (while taking estrogens in history); family hyperlipoproteinemia, pancreatitis, endometriosis, gallbladder disease in history (especially cholelithiasis), severe liver failure, jaundice (including one during pregnancy in history), hepatic porphyria, leiomyoma, hypercalcemia associated with bone metastases caused by breast cancer, underactive thyroid, porphyria, endometriosis, asthma.
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